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December 2008
Volume 1, Number 4
Cover Illustration:

The cover artistically depicts the results from the paper by Hamstra et.al. wherein head and neck tumors are treated using chemo-radiotherapy. Diffusion MRI is used as an early, non-invasive biomarker for therapeutic response.

TABLE OF CONTENTS

Original Report

Frequent S100A4 expression with unique splicing pattern in gastric cancers: A hypomethylation event paralleled with E-cadherin reduction and Wnt activation

Yan Li, Kai-Li Zhang, Yuan Sun, Yang Yang, Xiao-Yan Chen, Qing-You Kong, Mo-Li Wu, Jia Liu and Hong Li

Abstract   Full Article

Is autophagy rather than apoptosis the regression driver in Imatinib-treated gastrointestinal stromal tumours?

Francesca Miselli, Tiziana Negri, Alessandro Gronchi, Marco Losa, Elena Conca, Silvia Brich, Elena Fumagalli, Marco Fiore, Paolo G Casali, Marco A Pierotti, Elena Tamborini and Silvana Pilotti

Abstract   Full Article

Diffusion MRI: An imaging treatment response biomarker to chemoradiotherapy in a mouse model of squamous cell cancer of the head and neck

Daniel A Hamstra, Kuei C Lee, Bradford A Moffat, Thomas L Chenevert, Brian D. Ross and Alnawaz Rehemtulla

Abstract   Full Article

Enzastaurin, an inhibitor of PKCbeta, enhances anti-angiogenic effects and cytotoxicity of radiation against endothelial cells

Aaron C Spalding, Benjamin D Zeitlin, Kari Wilder-Romans, Mary A Davis, Jacques E Nor, Theodore S Lawrence and Edgar Ben-Josef

Abstract   Full Article

Detection of metastatic head and neck squamous cell carcinoma using the relative expression of tissue-specific Mir-205

aaron fletcher, Andrew C Heaford and Douglas K Trask

Abstract   Full Article

Review

Ecological therapy for cancer: Defining tumors utilizing an ecosystem paradigm suggests new opportunities for novel cancer treatments.

Kenneth J Pienta, Natalie McGregor, Robert Axelrod and David E Axelrod

Abstract   Full Article

 
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