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February 2010
Volume 3, Number 1
Cover Illustration:

The cover is an artistic depiction of results described in the paper by Blankenberg et.al. wherein VEGFR imaging has been shown to detect the effects of pazopanib, a tyrosine kinase inhibitor.

TABLE OF CONTENTS

Brief Article

Two-dimensional Fast surface imaging using a hand-held optical device: In-vitro and in-vivo fluorescence studies

Sarah J Erickson, Jiajia Ge, Andrea Sanchez and Anuradha Godavarty

Abstract   Full Article

Original Report

Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors

Isabela W Cunha, Kátia C Carvalho, Waleska W Martins, Sarah M Marques, Nair Muto, Roberto Falzoni, Rafael M Rocha, Samuel Aguiar Jr, Ana CQ Simoes, Lucas Fahham, Eduardo J Neves, Fernando A Soares and Luiz FL Reis

Abstract   Full Article

Evidence for DNA damage checkpoint activation in Barrett’s esophagus

Urs von Holzen, Tina Chen, Amelie Boquoi, Joel Richter, Gary W Falk, Andres J Klein-Szanto, Harry Cooper, Sam Litwin, David Weinberg and Greg H Enders

Abstract   Full Article

Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy

Nils Ole Schmidt, Mateo Ziu, Theresa Cargioli, Manfred Westphal, Alf Giese, Peter Black and Rona Carroll

Abstract   Full Article

Differential effects of the proteasome inhibitor NPI-0052 against glioma cells

Erina Vlashi, Malcolm Mattes, Chann Lagadec, Lorenza Della Donna, Tiffany Phillips, Polin Nikolay, William McBride and Frank Pajonk

Abstract   Full Article

Noninvasive assessment of tumor VEGF receptors in response to treatment with Pazopanib: A molecular imaging study

Francis G Blankenberg, Zoia Levashova, Susanta K Sarkar, John Pizzonia, Marina V Backer and Joseph M Backer

Abstract   Full Article

Review

Targeting p53 for novel anticancer therapy

Zhen Wang and Yi Sun

Abstract   Full Article

Three paths to better tyrosine kinase inhibition behind the blood-brain barrier in treating chronic myelogenous leukemia and glioblastoma with imatinib.

Daniele Focosi and Richard E. Kast

Abstract   Full Article

 
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