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December 2012
Volume 5, Number 6
Cover Illustration:

The cover represents an artistic depiction of the results described in the paper by Wang et al., wherein real-time high-resolution imaging with the aid of a tumor-targeting fluorescent contrast agent is demonstrated to enable intraoperative differentiation of tumor versus normal tissues with accuracy approaching the current gold standard of histopathology.

TABLE OF CONTENTS

Review Article

GENE SIGNATURES IN BREAST CANCER: CURRENT AND FUTURE USES

Enrique Espinosa, Juan Angel Fresno Vara, Angelo Gámez-Pozo and Pilar Zamora

Abstract   Full Article

Brief Article

A Systemic Complete Response of Metastatic Melanoma to Local Radiation and Immunotherapy

Susan Hiniker, Daniel S Chen, Sunil Reddy, Daniel T Chang, Jennifer C Jones, Joseph A Mollick, Susan M Swetter and Susan Knox

Abstract   Full Article

Research Article

Microscopic delineation of medulloblastoma margins in a transgenic mouse model using a topically applied VEGFR-1 probe

Danni Wang, Ye Chen, Steven Y Leigh, Henry Haeberle, Christopher H Contag and Jonathan T.C. Liu

Abstract   Full Article

Multi-Modality Imaging of Tumor and Bone Response in a Mouse Model of Boney Metastasis

Benjamin A Hoff, Komal Chughtai, Yong Hyun Jeon, Kenneth Kozloff, Stefanie Galban, Alnawaz Rehemtulla, Brian D. Ross and Craig J Galban

Abstract   Full Article

Evidence of mTOR activation by an AKT-independent mechanism provides support for the combined treatment of PTEN deficient prostate tumors with mTOR and AKT inhibitors

Weisheng Zhang, Brian B. Haines, Clay Efferson, Joe Zhu, Chris Ware, Kaiko Kunii, Jennifer Tammam, Minilik Angagaw, Marlene C. Hinton, Heike Keilhack, Cloud P. Paweletz, Theresa Zhang, Chris Winter, Sriram Sathyanarayanan, Jonathan Cheng, Leigh Zawel, Stephen Fawell, Gary Gilliland and Pradip K. Majumder

Abstract   Full Article

Analysis of the BRAFV600E mutation in central nervous system tumors

jaekyung myung, Hwajin Cho, Chul-Kee Park, Seung-Ki Kim, Se-Hoon Lee and Sung-Hye Park

Abstract   Full Article

Mapping Tumor Hypoxia In Vivo using Dynamic Contrast-Enhanced MRI (DCE-MRI)

Radka Stoyanova, Kris Huang, Kiri Sandler, HyungJoon Cho, Sean Carlin, Pat B Zanzonico, Jason A Koutcher and Ellen Ackerstaff

Abstract   Full Article

Polymorphisms of CHRNA5-CHRNA3-CHRNB4 gene cluster and NSCLC risk in Chinese population

Zhijun Li, Suzhen Bao, Xiaohong Xu, Yejiang Bao and yongjun zhang

Abstract   Full Article

The 16p13.3 (PDPK1) genomic gain in prostate cancer: a potential role in disease progression

Khalil A Choucair, Karl-Philippe Guérard, Joshua Ejdelman, Simone Chevalier, Maisa Yoshimoto, Eleonora Scarlata, Ladan Fazli, Kanishka Sircar, Jeremy A Squire, Fadi Brimo, Isabela W Cunha, Armen Aprikian, Martin Gleave and Jacques Lapointe

Abstract   Full Article

Specific biomarkers are associated with docetaxel and gemcitabine resistant NSCLC cell lines.

Alice Pasini, Giulia Paganelli, Anna Tesei, Wainer Zoli, Emanuele Giordano and Daniele Calistri

Abstract   Full Article

Histologic Parameters Predictive of Disease Outcome in Women with Advanced Stage Ovarian Carcinoma Treated with Neoadjuvant Chemotherapy.

Damanzoopinder samrao, Dan Wang, faith ough, Yvonne lin, song Liu, teodulo menesses, annie yessaian, nicole Turner, tanja Pejovic and paulette Mhawech-fauceglia

Abstract   Full Article

Heterogeneity of ERalpha and ErbB2 status in cell lines and circulating tumor cells of metastatic breast cancer patients

Carolin Bock, Brigitte Rack, Christina Kuhn, Simone Hofmann, Charlotte Finkenzeller, Bernadette Jäger, Udo Jeschke and Sophie F Doisneau-Sixou

Abstract   Full Article

Interpretation of changes in Circulating Tumor Cell counts

Frank Coumans, Sjoerd T Ligthart and Leon wmm Terstappen

Abstract   Full Article

Superior Therapeutic Index of Calmangafodipir in Comparison to Mangafodipir as a Chemotherapy Adjunct

Jan Olof G Karlsson, Tino Kurz, Jacques Näsström and Rolf G G Andersson

Abstract   Full Article

 
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